INMT

Across TCGA patient cohorts, INMT mutation is significantly associated with the RNA expression of many other genes, with 192 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible INMT-associated genes across cancer lineages are LINC02282, OR4A17P, and SNORD105. Each is linked with INMT in more than 1 cancer types. Because this analysis shows association rather than direction, both INMT-to-partner and partner-to-INMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02282 grouped by INMT-low versus INMT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (INMT→partner) and Y-score (partner→INMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02282 →	+0.250	+2.087	.007	.004	3	2
UCEC	OR4A17P →	+0.061	+3.505	.003	.005	3	2
LUSC	SNORD105 →	+0.581	+4.487	<.001	<.001	3	2
LUSC	OR9R1P →	+0.193	+3.827	<.001	.003	3	2
LUSC	DUTP4 →	+0.076	+3.623	.004	.005	3	2
LUAD	RPL31P13 →	+0.076	+4.315	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 192 associations by consensus.

LINC02282 by INMT expression — SKCM

Explore this box plot interactively →