INMT

Across TCGA pan-cancer cohorts, INMT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of INMT’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where INMT RNA is repressed in tumor relative to normal tissue. In most cancer types INMT is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

LUAD, BLCA, and KICH are the cancer types where INMT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in INMT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−4.626	<.001	11	view →
BLCA	Male	III,IV	−2.362	<.001	10	view →
KICH	All	III,IV	−2.279	<.001	10	view →
LUSC	Female	II,III,IV	−5.832	<.001	9	view →
KIRP	All	II,III,IV	−1.880	<.001	9	view →
KIRC	All	III,IV	−0.930	<.001	9	view →
LIHC	Male	All	−2.436	<.001	8	view →
HNSC	Male	All	−1.154	<.001	7	view →
UCEC	All	III,IV	−4.365	<.001	6	view →
BRCA	All	II,III,IV	−2.328	<.001	6	view →
PRAD	All	All	−1.119	<.001	2	view →
ESCA	Female	All	−1.190	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

INMT–LUAD

Open the LUAD breakdown →