ING4

Across TCGA patient cohorts, ING4 mutation is significantly associated with the RNA expression of many other genes, with 112 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ING4-associated genes across cancer lineages are MIR4535, PNLIPP1, and RNU5E-9P. Each is linked with ING4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ING4-to-partner and partner-to-ING4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4535 grouped by ING4-low versus ING4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ING4→partner) and Y-score (partner→ING4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4535 →	+0.428	+4.069	<.001	.008	3	3
LUAD	PNLIPP1 →	+0.127	+4.631	<.001	.008	3	2
UCEC	RNU5E-9P →	+0.366	+4.662	<.001	.003	3	2
CESC	RNA5SP162 →	+0.771	+5.103	<.001	.008	3	1
CESC	RN7SL847P →	+0.260	+5.010	<.001	.009	3	1
BRCA	RNU1-95P →	+0.228	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 112 associations by consensus.

MIR4535 by ING4 expression — UCEC

Explore this box plot interactively →