Q-omics provides the consensus-scored PNLIPP1 profile across patient tissues and cancer cell-line models. PNLIPP1 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, PNLIPP1 is differentially expressed in 1, with the highest sampling consensus in STAD. Additionally, PNLIPP1 RNA expression shows 6,258 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight LIHC, and STAD as cancer lineages where PNLIPP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PNLIPP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PNLIPP1 survival associations across molecular data types. PNLIPP1 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PNLIPP1 RNA expression–survival associations across cancer types. High PNLIPP1 expression shows unfavorable associations in LIHC, ACC, THCA, KIRC, OV and SARC. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for PNLIPP1 RNA expression.
This table summarizes PNLIPP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in STAD for RNA.
This table ranks reproducible tumor–normal expression differences for PNLIPP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PNLIPP1 shows higher tumor expression in STAD. The STAD box plot shows higher PNLIPP1 RNA expression in tumor versus normal tissue (log2 FC = +0.041, t-test p = .043).
This table shows molecular features associated with PNLIPP1 in patient tissues and cancer cell lines. In patient samples, PNLIPP1 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
