IMPA2

Across TCGA patient cohorts, IMPA2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,403 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible IMPA2-associated genes across cancer lineages are AFG3L2, TSPYL4, and RASGRF2. Each is linked with IMPA2 in more than 5 cancer types. Because this analysis shows association rather than direction, both IMPA2-to-partner and partner-to-IMPA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IMPA2 versus AFG3L2 in LSCC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IMPA2→partner) and Y-score (partner→IMPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AFG3L2 →	+0.576	+0.501	<.001	<.001	3	6
GBM	TSPYL4 →	-0.543	-0.692	<.001	<.001	3	6
GBM	RASGRF2 →	-0.787	-1.016	.008	<.001	3	6
UCEC	SPOCK1 →	-1.262	-0.454	.004	.007	3	6
BRCA	TIMP3 →	-1.126	-0.692	<.001	<.001	3	5
UCEC	RUNX2 →	-1.509	-0.539	<.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,403 associations by consensus.

IMPA2 vs AFG3L2 — LSCC

Explore this scatter interactively →