IL9R

Across TCGA patient cohorts, IL9R mutation is significantly associated with the RNA expression of many other genes, with 1,899 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL9R-associated genes across cancer lineages are PRAMEF12, RN7SKP43, and MIR4710. Each is linked with IL9R in more than 2 cancer types. Because this analysis shows association rather than direction, both IL9R-to-partner and partner-to-IL9R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF12 grouped by IL9R-low versus IL9R-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL9R→partner) and Y-score (partner→IL9R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	PRAMEF12 →	+0.045	+3.693	<.001	.006	3	2
READ	RN7SKP43 →	+0.163	+7.276	<.001	<.001	3	2
READ	MIR4710 →	+0.627	+5.219	<.001	.006	3	2
CESC	TNP1 →	+0.190	+5.507	<.001	<.001	3	2
UCEC	AP1S3 →	+0.620	+3.906	<.001	<.001	3	2
UCEC	ZDHHC7 →	+0.416	+2.321	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,899 associations by consensus.

PRAMEF12 by IL9R expression — SCLC

Explore this box plot interactively →