IL9R

Across TCGA pan-cancer cohorts, IL9R RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IL9R’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL9R RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL9R is over-expressed in tumor, although a few such as LUSC and PAAD show the opposite, repressed pattern.

KIRC, STAD, and BRCA are the cancer types where IL9R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL9R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.454	<.001	11	view →
STAD	All	II,III,IV	+0.535	<.001	8	view →
BRCA	All	II,III,IV	+0.432	<.001	6	view →
KIRP	All	III,IV	+0.271	.003	6	view →
UCEC	All	III,IV	+0.280	<.001	4	view →
LUSC	All	All	−0.259	.012	4	view →
LIHC	Female	All	+0.074	.007	3	view →
PAAD	Female	All	−1.305	.031	2	view →
CHOL	All	All	+0.360	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IL9R–KIRC

Open the KIRC breakdown →