IL6ST

Across TCGA patient cohorts, IL6ST mutation is significantly associated with the RNA expression of many other genes, with 2,257 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL6ST-associated genes across cancer lineages are RN7SL845P, RBM22P6, and LINC01072. Each is linked with IL6ST in more than 2 cancer types. Because this analysis shows association rather than direction, both IL6ST-to-partner and partner-to-IL6ST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL845P grouped by IL6ST-low versus IL6ST-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6ST→partner) and Y-score (partner→IL6ST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL845P →	+0.121	+5.241	.008	.007	3	3
SKCM	RBM22P6 →	+0.017	+3.009	.003	.009	3	2
CESC	LINC01072 →	+0.224	+5.345	<.001	.001	3	2
CESC	NF1P10 →	+0.175	+5.569	<.001	.002	3	2
UCEC	CYFIP1 →	+0.447	+2.439	.002	.001	3	2
UCEC	CASTOR2 →	+0.580	+3.480	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,257 associations by consensus.

RN7SL845P by IL6ST expression — HNSC

Explore this box plot interactively →