IL6ST

Across TCGA cell cohorts, IL6ST RNA expression is significantly associated with the go_rna of many other GO terms, with 6,571 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IL6ST-associated GO terms across cancer lineages are Negative regulation of cytokine activity, Leukemia inhibitory factor signaling pathway, and Interleukin-11-mediated signaling pathway. Each is linked with IL6ST in more than 19 cancer types. Because this analysis shows association rather than direction, both IL6ST-to-partner and partner-to-IL6ST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytokine activity grouped by IL6ST-low versus IL6ST-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6ST→partner) and Y-score (partner→IL6ST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of cytokine activity →	+1.436	+2.383	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Leukemia inhibitory factor signaling pathway →	+0.255	+1.515	<.001	.002	3	19
BREAST	Interleukin-11-mediated signaling pathway →	+0.260	+1.629	.009	<.001	3	18
LUNG_NSCLC_LUSC	Oncostatin-M-mediated signaling pathway →	+0.248	+2.392	.001	<.001	3	18
LUNG_SCLC	Alpha-beta T cell lineage commitment →	+0.228	+1.607	<.001	<.001	3	17
LUNG_NSCLC_LUSC	CD4-positive, alpha-beta T cell lineage commitment →	+0.316	+2.828	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,571 associations by consensus.

Negative regulation of cytokine activity by IL6ST expression — OESOPHAGUS

Explore this box plot interactively →