IL6ST

Across TCGA cell cohorts, IL6ST mutation is significantly associated with the RNA expression of many other genes, with 257 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL6ST-associated genes across cancer lineages are ZSWIM2, C1QA, and ZMYND8. Each is linked with IL6ST in more than 1 cancer types. Because this analysis shows association rather than direction, both IL6ST-to-partner and partner-to-IL6ST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSWIM2 grouped by IL6ST-low versus IL6ST-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6ST→partner) and Y-score (partner→IL6ST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZSWIM2 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1QA →	+0.206	+4.807	<.001	.006	3	1
LARGE_INTESTINE	ZMYND8 →	-0.777	-3.278	.003	.006	3	1
LARGE_INTESTINE	CTSZ →	-1.097	-3.278	.002	.006	3	1
LARGE_INTESTINE	PIM2 →	+0.596	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CLUAP1 →	+0.679	+3.082	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 257 associations by consensus.

ZSWIM2 by IL6ST expression — BLOOD_Myeloma

Explore this box plot interactively →