IL4I1

Across TCGA cell cohorts, IL4I1 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL4I1-associated genes across cancer lineages are KDM4E, ACTL7A, and TBC1D3. Each is linked with IL4I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL4I1-to-partner and partner-to-IL4I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDM4E grouped by IL4I1-low versus IL4I1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL4I1→partner) and Y-score (partner→IL4I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KDM4E →	+0.019	+4.523	.003	.004	3	2
LARGE_INTESTINE	ACTL7A →	+0.030	+3.823	<.001	.006	3	1
LARGE_INTESTINE	TBC1D3 →	+0.062	+3.688	<.001	.002	3	1
BLOOD_Lymphoma	FCN2 →	+0.048	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	OR52L1 →	+0.045	+4.191	.004	.007	3	1
BLOOD_Lymphoma	SCGB1C1 →	+0.177	+4.714	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

KDM4E by IL4I1 expression — BLOOD_Lymphoma

Explore this box plot interactively →