IL4I1

Across TCGA pan-cancer cohorts, IL4I1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of IL4I1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL4I1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL4I1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where IL4I1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL4I1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.125	<.001	12	view →
HNSC	Male	III,IV	+1.707	<.001	10	view →
COAD	Female	II,III,IV	+1.401	<.001	10	view →
LUAD	All	III,IV	+1.950	<.001	9	view →
THCA	All	IV	+2.630	<.001	8	view →
KIRP	Male	III,IV	+1.921	<.001	8	view →
STAD	Female	All	+2.768	<.001	7	view →
LIHC	All	II,III,IV	+1.169	<.001	7	view →
LUSC	Female	II,III,IV	+1.797	<.001	6	view →
BRCA	All	All	+1.621	<.001	6	view →
BLCA	Male	All	+1.086	.026	4	view →
KICH	All	II,III,IV	−0.934	.012	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

IL4I1–KIRC

Open the KIRC breakdown →