IL31RA

Across TCGA patient cohorts, IL31RA mutation is significantly associated with the RNA expression of many other genes, with 4,993 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL31RA-associated genes across cancer lineages are OXNAD1, ABRAXAS2, and ZNF37A. Each is linked with IL31RA in more than 2 cancer types. Because this analysis shows association rather than direction, both IL31RA-to-partner and partner-to-IL31RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXNAD1 grouped by IL31RA-low versus IL31RA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL31RA→partner) and Y-score (partner→IL31RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OXNAD1 →	+0.246	+1.758	.004	<.001	3	3
UCEC	ABRAXAS2 →	+0.410	+1.747	<.001	<.001	3	3
UCEC	ZNF37A →	+0.318	+1.758	.002	<.001	3	3
UCEC	TIMM44 →	+0.386	+2.224	<.001	<.001	3	3
SKCM	EXOSC3 →	+0.331	+1.873	.009	.004	3	3
UCEC	ANKRD26 →	+0.309	+3.087	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,993 associations by consensus.

OXNAD1 by IL31RA expression — UCEC

Explore this box plot interactively →