IL31RA

Across TCGA pan-cancer cohorts, IL31RA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IL31RA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL31RA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL31RA is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where IL31RA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL31RA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.716	<.001	11	view →
LUAD	Male	II,III,IV	+1.613	<.001	9	view →
LUSC	Male	All	+0.909	<.001	7	view →
KIRP	All	All	+0.222	.009	6	view →
THCA	All	All	+0.093	<.001	5	view →
CHOL	All	All	+0.201	.017	4	view →
BRCA	Female	All	+0.078	.003	4	view →
LIHC	All	All	+0.062	.003	3	view →
PRAD	All	All	+0.459	<.001	2	view →
READ	Male	All	+0.176	.007	2	view →
KIRC	Male	All	+0.130	.004	2	view →
BLCA	Female	All	+0.120	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IL31RA–HNSC

Open the HNSC breakdown →