IL31RA

Across TCGA pan-cancer cohorts, IL31RA RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated IL31RA data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher IL31RA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IL31RA expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UVM, MESO, and ACC are the cancer types where IL31RA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.319	0.755	<.001	116	view →
MESO	OS	Median	All	0.227	0.733	<.001	78	view →
ACC	DFS	Median	All	0.255	0.586	.001	58	view →
UCEC	DFS	Tertile	II,III,IV	0.722	0.423	.001	54	view →
SKCM	OS	Median	All	0.422	0.262	<.001	54	view →
PAAD	DFS	Quartile	All	0.227	0.500	<.001	48	view →
LGG	DFS	Median	All	0.293	0.476	<.001	44	view →
OV	DFS	Quartile	All	0.465	0.326	.001	42	view →
HNSC	OS	Tertile	All	0.628	0.752	.014	30	view →
KIRP	DFS	Tertile	IV	0.039	0.765	.006	27	view →
STAD	OS	Quartile	III,IV	0.295	0.649	.004	25	view →
LAML	DFS	Tertile	All	0.409	0.761	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

IL31RA–UVM (OS)

Open the UVM breakdown →