IL31RA

Across TCGA patient cohorts, IL31RA mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL31RA-associated genes across cancer lineages are Akt_pS473, p62 Lck ligand, and Akt_pT308. Each is linked with IL31RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL31RA-to-partner and partner-to-IL31RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pS473 grouped by IL31RA-low versus IL31RA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL31RA→partner) and Y-score (partner→IL31RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pS473 →	+0.597	+1.925	.008	.004	3	2
UCEC	p62 Lck ligand →	+0.276	+1.777	.007	.002	3	2
UCEC	Akt_pT308 →	+0.537	+1.777	.007	.002	3	2
UCEC	Annexin-1 →	+0.486	+1.827	.003	.015	3	2
UCEC	TFRC →	+0.366	+2.459	.031	.018	3	2
UCEC	ASNS →	+0.290	+1.289	.012	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Akt_pS473 by IL31RA expression — UCEC

Explore this box plot interactively →