IL31RA

Across TCGA cell cohorts, IL31RA mutation is significantly associated with the RNA expression of many other genes, with 851 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL31RA-associated genes across cancer lineages are OR1N2, SPRR1A, and ARHGAP36. Each is linked with IL31RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL31RA-to-partner and partner-to-IL31RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1N2 grouped by IL31RA-low versus IL31RA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL31RA→partner) and Y-score (partner→IL31RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR1N2 →	+0.033	+3.705	<.001	.007	3	2
BLOOD_Myeloma	SPRR1A →	+1.269	+3.906	<.001	.009	3	1
BLOOD_Leukemia	ARHGAP36 →	+0.016	+3.944	<.001	.006	3	1
BLOOD_Leukemia	OR1N1 →	+0.073	+4.234	<.001	.003	3	1
BLOOD_Leukemia	CCT8L2 →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	TCEAL6 →	+0.026	+4.133	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 851 associations by consensus.

OR1N2 by IL31RA expression — BLOOD_Leukemia

Explore this box plot interactively →