IL27RA

Across TCGA cell cohorts, IL27RA mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL27RA-associated genes across cancer lineages are KHDC3L, CST8, and CRYBB1. Each is linked with IL27RA in more than 1 cancer types. Because this analysis shows association rather than direction, both IL27RA-to-partner and partner-to-IL27RA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by IL27RA-low versus IL27RA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL27RA→partner) and Y-score (partner→IL27RA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KHDC3L →	+0.023	+2.882	<.001	.005	3	2
BLOOD_Leukemia	CST8 →	+0.031	+3.969	<.001	.009	3	2
BREAST	CRYBB1 →	+0.280	+4.781	<.001	.003	3	1
BREAST	IFNA6 →	+0.090	+4.781	<.001	.003	3	1
LARGE_INTESTINE	IL20 →	+0.208	+4.247	<.001	<.001	3	1
LARGE_INTESTINE	LMOD2 →	+0.168	+3.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

KHDC3L by IL27RA expression — LARGE_INTESTINE

Explore this box plot interactively →