IL27RA

Across TCGA pan-cancer cohorts, IL27RA RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of IL27RA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL27RA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL27RA is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where IL27RA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL27RA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.236	<.001	11	view →
COAD	All	III,IV	+0.996	<.001	11	view →
LIHC	Female	II,III,IV	+1.310	<.001	9	view →
HNSC	All	All	+1.003	<.001	9	view →
KICH	Male	All	−2.036	<.001	8	view →
KIRP	Male	II,III,IV	+1.247	.001	8	view →
THCA	All	II,III,IV	+0.921	<.001	8	view →
STAD	Male	II,III,IV	+1.503	<.001	7	view →
BRCA	Female	II,III,IV	−0.677	<.001	6	view →
LUAD	Female	All	+0.549	<.001	6	view →
CHOL	Male	All	+2.540	<.001	3	view →
BLCA	Male	III,IV	+1.207	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

IL27RA–KIRC

Open the KIRC breakdown →