IL24

Across TCGA cell cohorts, IL24 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL24-associated genes across cancer lineages are MSGN1, SAXO1, and C14orf180. Each is linked with IL24 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL24-to-partner and partner-to-IL24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by IL24-low versus IL24-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL24→partner) and Y-score (partner→IL24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	SAXO1 →	+0.050	+3.556	<.001	.007	3	1
LARGE_INTESTINE	C14orf180 →	+0.168	+3.155	<.001	.008	3	1
LARGE_INTESTINE	LCE1B →	+0.153	+3.878	<.001	.003	3	1
LARGE_INTESTINE	LCN8 →	+0.162	+4.125	<.001	.003	3	1
LARGE_INTESTINE	KRTAP10-3 →	+0.042	+4.242	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MSGN1 by IL24 expression — LARGE_INTESTINE

Explore this box plot interactively →