IL23R

Across TCGA patient cohorts, IL23R mutation is significantly associated with the RNA expression of many other genes, with 1,003 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL23R-associated genes across cancer lineages are OR5K4, RAB28P1, and ATF1P1. Each is linked with IL23R in more than 2 cancer types. Because this analysis shows association rather than direction, both IL23R-to-partner and partner-to-IL23R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5K4 grouped by IL23R-low versus IL23R-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL23R→partner) and Y-score (partner→IL23R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR5K4 →	+0.026	+4.786	.001	.004	3	3
STAD	RAB28P1 →	+0.157	+3.646	<.001	.009	3	3
COAD	ATF1P1 →	+0.228	+6.392	.003	.001	3	2
COAD	UBL5P1 →	+0.390	+5.283	<.001	.006	3	2
UCEC	TSPAN7 →	-1.374	-3.443	<.001	.005	3	2
UCEC	CKAP2L →	+0.653	+2.332	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,003 associations by consensus.

OR5K4 by IL23R expression — BRCA

Explore this box plot interactively →