IL23R

Across TCGA pan-cancer cohorts, IL23R RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IL23R data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IL23R RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IL23R expression acts as an unfavorable survival marker, although some lineages such as HNSC and CHOL show a favorable association.

HNSC, CHOL, and LUAD are the cancer types where IL23R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.693	0.535	.001	58	view →
CHOL	DFS	Tertile	All	1.000	0.189	<.001	53	view →
LUAD	OS	Median	All	0.894	0.773	.001	49	view →
LGG	DFS	Tertile	All	0.626	0.774	<.001	41	view →
ACC	DFS	Median	All	0.511	0.804	<.001	38	view →
KIRP	DFS	Median	All	0.635	0.881	.013	31	view →
BRCA	OS	Median	II,III,IV	0.969	0.945	.009	23	view →
SKCM	OS	Tertile	All	0.830	0.732	.006	20	view →
SCLC	DFS	Median	All	0.744	0.490	.002	18	view →
ESCA	OS	Tertile	All	0.568	1.000	.028	15	view →
DLBC	DFS	Median	III,IV	1.000	0.403	.003	13	view →
BLCA	DFS	Quartile	All	0.715	0.548	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IL23R–HNSC (DFS)

Open the HNSC breakdown →