IL23R

Across TCGA pan-cancer cohorts, IL23R RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IL23R’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IL23R RNA is repressed in tumor relative to normal tissue. In most cancer types IL23R is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and KICH are the cancer types where IL23R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL23R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.440	<.001	6	view →
LUSC	Male	All	−0.097	.001	6	view →
KICH	All	II,III,IV	−0.072	<.001	6	view →
LUAD	All	IV	−0.175	.049	2	view →
KIRC	Male	All	+0.120	.001	2	view →
CHOL	All	II,III,IV	−0.035	.019	2	view →
THCA	All	All	−0.029	.017	2	view →
STAD	All	All	+0.203	.018	1	view →
LIHC	Female	III,IV	+0.102	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IL23R–COAD

Open the COAD breakdown →