IL23R

Across TCGA patient cohorts, IL23R mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL23R-associated genes across cancer lineages are PDCD4, PKC-b-II_pS660, and MEK1. Each is linked with IL23R in more than 1 cancer types. Because this analysis shows association rather than direction, both IL23R-to-partner and partner-to-IL23R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by IL23R-low versus IL23R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL23R→partner) and Y-score (partner→IL23R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.721	-3.169	.001	.018	3	2
UCEC	PKC-b-II_pS660 →	-0.356	-3.321	.007	.010	3	2
UCEC	MEK1 →	+0.473	+3.169	.007	.018	3	1
UCEC	PKC-a_pS657 →	-0.386	-2.999	.036	.035	3	1
UCEC	Src_pY416 →	-0.236	-2.446	.042	.020	3	1
UCEC	Src_pY527 →	-0.449	-2.990	.030	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PDCD4 by IL23R expression — UCEC

Explore this box plot interactively →