IL23R

Across TCGA cell cohorts, IL23R mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IL23R-associated genes across cancer lineages are IQCF5, MYH4, and COL6A5. Each is linked with IL23R in more than 1 cancer types. Because this analysis shows association rather than direction, both IL23R-to-partner and partner-to-IL23R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by IL23R-low versus IL23R-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL23R→partner) and Y-score (partner→IL23R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	2
BLOOD_Leukemia	MYH4 →	+0.006	+5.969	<.001	.001	3	2
OESOPHAGUS	COL6A5 →	+0.300	+4.017	.002	.007	3	1
OESOPHAGUS	KRTAP5-5 →	+0.121	+4.392	<.001	.003	3	1
OESOPHAGUS	CHAT →	+0.110	+4.017	.004	.007	3	1
CNS	USP17L3 →	+0.005	+4.044	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

IQCF5 by IL23R expression — BLOOD_Leukemia

Explore this box plot interactively →