IL21R

Across TCGA patient cohorts, IL21R mutation is significantly associated with the RNA expression of many other genes, with 2,508 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL21R-associated genes across cancer lineages are ELOA-AS1, CBX1P5, and SNHG30. Each is linked with IL21R in more than 2 cancer types. Because this analysis shows association rather than direction, both IL21R-to-partner and partner-to-IL21R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA-AS1 grouped by IL21R-low versus IL21R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL21R→partner) and Y-score (partner→IL21R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELOA-AS1 →	+0.364	+3.087	.001	<.001	3	3
COAD	CBX1P5 →	+0.068	+4.602	<.001	.003	3	3
LUAD	SNHG30 →	+0.585	+2.700	.003	.006	3	3
LUAD	BSNDP4 →	+0.060	+3.444	.001	.003	3	3
OV	SUCLA2P2 →	+0.052	+4.475	<.001	.009	3	3
UCEC	CENPM →	+0.636	+3.711	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,508 associations by consensus.

ELOA-AS1 by IL21R expression — UCEC

Explore this box plot interactively →