IL21R

Across TCGA pan-cancer cohorts, IL21R RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IL21R’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IL21R RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL21R is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, HNSC, and BRCA are the cancer types where IL21R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL21R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.456	<.001	12	view →
HNSC	All	All	+0.668	<.001	11	view →
BRCA	All	All	+1.198	<.001	8	view →
STAD	All	II,III,IV	+1.170	<.001	8	view →
LUAD	All	All	+0.497	.001	5	view →
THCA	All	IV	+1.000	.021	2	view →
ESCA	All	All	+0.965	.010	2	view →
CHOL	All	All	+0.992	.012	1	view →
LUSC	Male	III,IV	−0.577	.023	1	view →
KIRP	All	All	+0.310	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IL21R–KIRC

Open the KIRC breakdown →