IL21R

Across TCGA pan-cancer cohorts, IL21R RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IL21R data layer compared with 5 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IL21R RNA is associated with better overall survival. In most high-consensus cancer types, elevated IL21R expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and UVM are the cancer types where IL21R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.436	0.246	<.001	140	view →
HNSC	DFS	Median	All	0.765	0.653	<.001	121	view →
UVM	DFS	Tertile	II,III,IV	0.348	0.693	<.001	92	view →
KIRP	DFS	Tertile	All	0.760	0.917	<.001	86	view →
LUAD	OS	Tertile	II,III,IV	0.654	0.309	<.001	71	view →
CESC	DFS	Median	All	0.807	0.663	.002	68	view →
UCEC	OS	Tertile	III,IV	0.773	0.360	.001	62	view →
SCLC	DFS	Median	III,IV	0.704	0.355	.007	26	view →
KIRC	DFS	Tertile	IV	0.205	0.477	.008	24	view →
CHOL	DFS	Median	All	0.620	0.199	.010	16	view →
LAML	DFS	Tertile	All	0.319	0.650	.005	12	view →
UCS	DFS	Tertile	IV	0.942	0.364	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IL21R–SKCM (OS)

Open the SKCM breakdown →