IL21R

Across TCGA cell cohorts, IL21R RNA expression is significantly associated with the go_rna of many other GO terms, with 2,272 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IL21R-associated GO terms across cancer lineages are Aorta smooth muscle tissue morphogenesis, Actin polymerization or depolymerization, and Positive regulation of protein deubiquitination. Each is linked with IL21R in more than 5 cancer types. Because this analysis shows association rather than direction, both IL21R-to-partner and partner-to-IL21R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aorta smooth muscle tissue morphogenesis grouped by IL21R-low versus IL21R-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IL21R→partner) and Y-score (partner→IL21R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Aorta smooth muscle tissue morphogenesis →	+1.020	+0.388	<.001	.007	3	6
BONE	Actin polymerization or depolymerization →	+0.124	+0.894	<.001	.002	3	6
BLOOD_Lymphoma	Positive regulation of protein deubiquitination →	+0.126	+2.462	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Glycolytic process through fructose-6-phosphate →	+0.072	+0.136	.003	<.001	2	6
UPPER_AERODIGESTIVE_TRACT	Glycolytic process through glucose-6-phosphate →	+0.072	+0.136	.003	<.001	2	6
LIVER	Protein O-linked glycosylation →	+0.037	+0.350	.007	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,272 associations by consensus.

Aorta smooth muscle tissue morphogenesis by IL21R expression — SKIN

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