IL21R

Across TCGA cell cohorts, IL21R mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL21R-associated genes across cancer lineages are Niraparib, PCI-34051, and AZD5153. Each is linked with IL21R in more than 1 cancer types. Because this analysis shows association rather than direction, both IL21R-to-partner and partner-to-IL21R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by IL21R-low versus IL21R-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL21R→partner) and Y-score (partner→IL21R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.439	+2.646	.012	.047	3	1
LARGE_INTESTINE	PCI-34051 →	+0.395	+2.646	.040	.047	3	1
LARGE_INTESTINE	AZD5153 →	+0.682	+2.649	.005	.046	3	1
LARGE_INTESTINE	50869 →	+0.445	+2.649	.035	.046	3	1
LARGE_INTESTINE	PHA-793887 →	+0.762	+2.652	.037	.045	3	1
LARGE_INTESTINE	Vincristine →	+0.858	+2.649	.048	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Niraparib by IL21R expression — LARGE_INTESTINE

Explore this box plot interactively →