IL1RN

Across TCGA patient cohorts, IL1RN protein abundance is significantly associated with the RNA expression of many other genes, with 14,181 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IL1RN-associated genes across cancer lineages are PI3, SDCBP2, and NECTIN4. Each is linked with IL1RN in more than 4 cancer types. Because this analysis shows association rather than direction, both IL1RN-to-partner and partner-to-IL1RN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL1RN versus PI3 in GBM, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1RN→partner) and Y-score (partner→IL1RN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PI3 →	+2.561	+0.630	<.001	<.001	3	5
HNSC	SDCBP2 →	+1.249	+0.761	<.001	<.001	3	5
LSCC	NECTIN4 →	+1.017	+0.887	<.001	<.001	3	5
LSCC	PLCD3 →	+0.816	+1.249	<.001	<.001	3	5
GBM	METRNL →	+1.157	+0.776	<.001	<.001	3	5
COAD	HCAR2 →	+3.425	+1.001	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,181 associations by consensus.

IL1RN vs PI3 — GBM

Explore this scatter interactively →