IL1RAPL1

Across TCGA cell cohorts, IL1RAPL1 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL1RAPL1-associated genes across cancer lineages are SHISAL2B, OR2M4, and C22orf31. Each is linked with IL1RAPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL1RAPL1-to-partner and partner-to-IL1RAPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHISAL2B grouped by IL1RAPL1-low versus IL1RAPL1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1RAPL1→partner) and Y-score (partner→IL1RAPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SHISAL2B →	+0.796	+4.087	<.001	.004	3	2
OVARY	OR2M4 →	+0.070	+4.700	<.001	.002	3	2
LUNG_NSCLC_LUAD	C22orf31 →	+0.042	+4.050	<.001	.004	3	1
LUNG_NSCLC_LUAD	CABS1 →	+0.009	+4.472	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR7G1 →	+0.014	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR2AP1 →	+0.009	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

SHISAL2B by IL1RAPL1 expression — CNS

Explore this box plot interactively →