IL1RAPL1

Across TCGA pan-cancer cohorts, IL1RAPL1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IL1RAPL1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where IL1RAPL1 RNA is repressed in tumor relative to normal tissue. In most cancer types IL1RAPL1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and THCA are the cancer types where IL1RAPL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL1RAPL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.473	<.001	10	view →
COAD	Male	II,III,IV	−0.150	<.001	9	view →
THCA	Female	All	−0.379	<.001	6	view →
READ	All	All	−0.277	.003	4	view →
BRCA	All	All	−0.116	<.001	4	view →
UCEC	All	II,III,IV	−0.108	.021	4	view →
LIHC	Male	All	+0.156	.024	3	view →
KICH	All	III,IV	−0.107	.006	3	view →
PRAD	All	All	+0.601	<.001	2	view →
CHOL	All	All	+0.150	.032	2	view →
KIRC	All	All	+0.061	.010	2	view →
STAD	All	All	−0.249	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IL1RAPL1–BLCA

Open the BLCA breakdown →