IL17RE

Across TCGA patient cohorts, IL17RE mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL17RE-associated genes across cancer lineages are PCNA, Caspase-8, and EGFR_pY1068. Each is linked with IL17RE in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17RE-to-partner and partner-to-IL17RE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by IL17RE-low versus IL17RE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17RE→partner) and Y-score (partner→IL17RE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.292	+2.700	.002	.006	3	2
UCEC	Caspase-8 →	-0.225	-3.143	.047	.018	3	2
UCEC	EGFR_pY1068 →	-0.235	-2.700	.037	.006	3	1
UCEC	FoxM1 →	+0.257	+2.700	.027	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.156	-1.986	.040	.032	3	1
UCEC	Ku80 →	+0.328	+2.713	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PCNA by IL17RE expression — UCEC

Explore this box plot interactively →