IL17RE

Across TCGA cell cohorts, IL17RE mutation is significantly associated with the drug of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IL17RE-associated genes across cancer lineages are KU-55933, SGC-CBP30, and GSK2578215A. Each is linked with IL17RE in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17RE-to-partner and partner-to-IL17RE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KU-55933 grouped by IL17RE-low versus IL17RE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17RE→partner) and Y-score (partner→IL17RE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KU-55933 →	+0.355	+2.807	.049	.046	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.285	+2.871	.033	.021	3	1
LARGE_INTESTINE	GSK2578215A →	+0.310	+2.871	.038	.021	3	1
LARGE_INTESTINE	Quizartinib →	+0.396	+2.874	.008	.021	3	1
LARGE_INTESTINE	Vismodegib →	+0.402	+2.684	.003	.035	2	1
LARGE_INTESTINE	GSK2801 →	+0.341	+2.871	.023	.021	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

KU-55933 by IL17RE expression — LARGE_INTESTINE

Explore this box plot interactively →