IL17RB

Across TCGA patient cohorts, IL17RB mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL17RB-associated genes across cancer lineages are EGFR_pY1068, JNK2, and PCNA. Each is linked with IL17RB in more than 1 cancer types. Because this analysis shows association rather than direction, both IL17RB-to-partner and partner-to-IL17RB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by IL17RB-low versus IL17RB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL17RB→partner) and Y-score (partner→IL17RB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.259	-2.115	.018	.019	3	1
UCEC	JNK2 →	+0.226	+2.115	.009	.019	3	1
UCEC	PCNA →	+0.253	+3.321	.007	.010	3	1
UCEC	PDCD4 →	-0.476	-3.169	.020	.018	3	1
UCEC	Annexin-1 →	+0.568	+3.019	.013	.019	3	1
UCEC	STAT3_pY705 →	-0.414	-2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by IL17RB expression — UCEC

Explore this box plot interactively →