IL17RB

Across TCGA pan-cancer cohorts, IL17RB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IL17RB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IL17RB RNA is repressed in tumor relative to normal tissue. In most cancer types IL17RB is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, STAD, and LIHC are the cancer types where IL17RB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL17RB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.538	<.001	11	view →
STAD	All	III,IV	+2.530	<.001	10	view →
LIHC	Female	III,IV	+1.637	<.001	8	view →
READ	All	II,III,IV	+1.207	<.001	7	view →
COAD	Male	II,III,IV	+0.881	<.001	7	view →
UCEC	All	III,IV	+1.352	<.001	6	view →
LUSC	Male	II,III,IV	−1.194	<.001	6	view →
KIRP	All	III,IV	−1.634	.001	5	view →
KIRC	Male	III,IV	−1.054	.008	5	view →
PRAD	All	All	+0.678	<.001	2	view →
BLCA	All	All	+0.538	.033	2	view →
THCA	All	All	−0.270	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IL17RB–KICH

Open the KICH breakdown →