IL12RB1

Across TCGA patient cohorts, IL12RB1 mutation is significantly associated with the RNA expression of many other genes, with 2,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL12RB1-associated genes across cancer lineages are RNU6-503P, RN7SL645P, and MTCO1P30. Each is linked with IL12RB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IL12RB1-to-partner and partner-to-IL12RB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-503P grouped by IL12RB1-low versus IL12RB1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12RB1→partner) and Y-score (partner→IL12RB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-503P →	+0.849	+5.044	<.001	.009	3	3
CESC	RN7SL645P →	+0.147	+4.669	<.001	.007	3	2
SKCM	MTCO1P30 →	+0.137	+2.774	.002	<.001	3	2
UCEC	RN7SL248P →	+0.040	+2.552	<.001	.003	3	2
UCEC	LINC01730 →	+0.226	+1.936	.006	.002	3	2
UCEC	RNA5SP412 →	+0.462	+1.382	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,109 associations by consensus.

RNU6-503P by IL12RB1 expression — LUAD

Explore this box plot interactively →