IL12B

Across TCGA patient cohorts, IL12B mutation is significantly associated with the RNA expression of many other genes, with 862 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL12B-associated genes across cancer lineages are RN7SL248P, RNU6-660P, and RNU4-31P. Each is linked with IL12B in more than 1 cancer types. Because this analysis shows association rather than direction, both IL12B-to-partner and partner-to-IL12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by IL12B-low versus IL12B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL12B→partner) and Y-score (partner→IL12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.082	+3.635	<.001	<.001	3	2
LUSC	RNU6-660P →	+0.654	+6.906	<.001	<.001	3	2
CESC	RNU4-31P →	+0.281	+4.874	<.001	.002	3	2
CESC	IGHD6-13 →	+1.613	+4.816	<.001	.003	3	2
CESC	CCL27 →	+0.065	+4.812	<.001	.006	3	2
COAD	DNAJA1P1 →	+0.230	+4.081	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 862 associations by consensus.

RN7SL248P by IL12B expression — UCEC

Explore this box plot interactively →