IL12B

Across TCGA pan-cancer cohorts, IL12B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IL12B data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher IL12B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IL12B expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

UVM, BRCA, and SKCM are the cancer types where IL12B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.350	0.674	<.001	108	view →
BRCA	DFS	Median	All	0.579	0.465	<.001	94	view →
SKCM	OS	Tertile	All	0.479	0.282	<.001	86	view →
KIRP	DFS	Quartile	All	0.728	0.934	<.001	82	view →
LUAD	DFS	Median	All	0.733	0.593	<.001	81	view →
CESC	DFS	Median	All	0.885	0.752	<.001	72	view →
HNSC	DFS	Quartile	All	0.779	0.641	.002	66	view →
KIRC	OS	Quartile	II,III,IV	0.815	0.619	.003	53	view →
SCLC	DFS	Median	II,III,IV	0.519	0.201	.005	20	view →
SARC	OS	Quartile	All	0.650	0.417	.001	19	view →
COAD	DFS	Tertile	III,IV	0.687	0.437	.011	13	view →
ESCA	DFS	Tertile	III,IV	0.513	0.196	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IL12B–UVM (DFS)

Open the UVM breakdown →