IKZF3

Across TCGA patient cohorts, IKZF3 mutation is significantly associated with the RNA expression of many other genes, with 1,866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKZF3-associated genes across cancer lineages are RNU6-750P, LINC02155, and SKA1. Each is linked with IKZF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IKZF3-to-partner and partner-to-IKZF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-750P grouped by IKZF3-low versus IKZF3-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF3→partner) and Y-score (partner→IKZF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-750P →	+0.503	+5.039	<.001	.008	3	2
READ	LINC02155 →	+0.437	+6.257	<.001	.001	3	2
UCEC	SKA1 →	+0.742	+2.513	<.001	.001	3	2
UCEC	DFFA →	+0.418	+2.053	.003	.005	3	2
UCEC	PAQR3 →	+0.521	+3.480	.001	.002	3	2
UCEC	RCHY1 →	+0.464	+2.617	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,866 associations by consensus.

RNU6-750P by IKZF3 expression — READ

Explore this box plot interactively →