IKZF3

Across TCGA pan-cancer cohorts, IKZF3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IKZF3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IKZF3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IKZF3 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where IKZF3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IKZF3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.770	<.001	11	view →
COAD	Female	All	−0.952	<.001	10	view →
THCA	All	IV	+1.745	.002	8	view →
STAD	All	All	+1.120	.003	5	view →
LUSC	All	All	−0.510	.003	5	view →
BLCA	Male	All	+1.348	.009	4	view →
UCEC	All	III,IV	+1.123	.034	4	view →
BRCA	All	All	+0.490	.001	4	view →
LUAD	All	All	+0.517	.004	2	view →
ESCA	All	All	+1.210	.009	1	view →
KIRP	All	All	+0.476	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IKZF3–KIRC

Open the KIRC breakdown →