IKZF2

Across TCGA patient cohorts, IKZF2 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,681 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible IKZF2-associated proteins across cancer lineages are IKZF2_S56, IKZF2_S433, and TTC9. Each is linked with IKZF2 in more than 7 cancer types. Because this analysis shows association rather than direction, both IKZF2-to-partner and partner-to-IKZF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IKZF2 versus IKZF2_S56 in LSCC, with a Pearson correlation of 0.75.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF2→partner) and Y-score (partner→IKZF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IKZF2_S56 →	+0.683	+0.854	<.001	<.001	3	8
BRCA	IKZF2_S433 →	+0.764	+0.927	<.001	<.001	3	7
LSCC	TTC9 →	+0.594	+0.750	<.001	<.001	3	5
OV	PPIF →	-0.615	-0.554	<.001	.008	3	4
LUAD	INPP4B →	+0.753	+0.532	.001	<.001	3	4
HNSC	KRT19 →	+1.249	+1.014	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,681 associations by consensus.

IKZF2 vs IKZF2_S56 — LSCC

Explore this scatter interactively →