IKZF2

Across TCGA patient cohorts, IKZF2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,191 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IKZF2-associated genes across cancer lineages are VAV3, THRB, and C4orf33. Each is linked with IKZF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IKZF2-to-partner and partner-to-IKZF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IKZF2 versus VAV3 in BRCA, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF2→partner) and Y-score (partner→IKZF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VAV3 →	+1.997	+0.889	<.001	.004	3	3
BRCA	THRB →	+1.106	+0.858	<.001	<.001	3	3
BRCA	C4orf33 →	+0.706	+0.788	.001	.006	3	3
BRCA	SIDT1 →	+1.128	+0.806	.005	<.001	3	3
HNSC	PLAAT4 →	+1.265	+0.481	<.001	<.001	3	3
LUAD	ADGRF1 →	+1.922	+0.351	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,191 associations by consensus.

IKZF2 vs VAV3 — BRCA

Explore this scatter interactively →