IKZF2

Across TCGA cell cohorts, IKZF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,930 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IKZF2-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Stress granule assembly, and Golgi vesicle budding. Each is linked with IKZF2 in more than 13 cancer types. Because this analysis shows association rather than direction, both IKZF2-to-partner and partner-to-IKZF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by IKZF2-low versus IKZF2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF2→partner) and Y-score (partner→IKZF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of alternative mRNA splicing, via spliceosome →	+0.123	+2.142	.001	.001	3	14
OVARY	Stress granule assembly →	+0.108	+1.047	<.001	.001	3	12
LUNG_NSCLC_LUAD	Golgi vesicle budding →	+0.135	+1.420	<.001	<.001	3	12
OESOPHAGUS	Small GTPase-mediated signal transduction →	+0.075	+2.213	<.001	<.001	3	11
OESOPHAGUS	Rho protein signal transduction →	+0.137	+1.865	.001	<.001	2	12
OVARY	Regulation of cytoplasmic translation →	+0.121	+1.375	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,930 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by IKZF2 expression — URINARY_TRACT

Explore this box plot interactively →