IKZF2

Across TCGA cell cohorts, IKZF2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IKZF2-associated genes across cancer lineages are CEACAM4, SLC38A8, and MAGEL2. Each is linked with IKZF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IKZF2-to-partner and partner-to-IKZF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM4 grouped by IKZF2-low versus IKZF2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF2→partner) and Y-score (partner→IKZF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CEACAM4 →	+0.053	+4.927	<.001	.001	3	1
BLOOD_Lymphoma	SLC38A8 →	+0.054	+4.191	.009	.007	3	1
BLOOD_Lymphoma	MAGEL2 →	+0.017	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CEACAM4 by IKZF2 expression — BLOOD_Lymphoma

Explore this box plot interactively →