IGSF5

Across TCGA cell cohorts, IGSF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,651 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IGSF5-associated GO terms across cancer lineages are Nuclear pore complex assembly, Glycerophospholipid metabolic process, and Protein localization to plasma membrane. Each is linked with IGSF5 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGSF5-to-partner and partner-to-IGSF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear pore complex assembly grouped by IGSF5-low versus IGSF5-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF5→partner) and Y-score (partner→IGSF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Nuclear pore complex assembly →	-0.113	-0.843	<.001	.001	3	6
PANCREAS	Glycerophospholipid metabolic process →	+0.035	+0.680	.008	.003	3	6
LUNG_NSCLC_LUSC	Protein localization to plasma membrane →	+0.074	+0.178	<.001	<.001	3	5
PANCREAS	Smooth muscle cell migration →	+0.189	+0.647	.001	.004	3	5
PANCREAS	Regulation of L-glutamate import across plasma membrane →	+0.135	+0.358	<.001	<.001	3	5
BREAST	Nuclear pore organization →	-0.099	-0.817	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,651 associations by consensus.

Nuclear pore complex assembly by IGSF5 expression — BREAST

Explore this box plot interactively →