IGSF5

Across TCGA pan-cancer cohorts, IGSF5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IGSF5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IGSF5 RNA is repressed in tumor relative to normal tissue. In most cancer types IGSF5 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BRCA are the cancer types where IGSF5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGSF5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.631	<.001	12	view →
KICH	Male	II,III,IV	−0.887	<.001	11	view →
BRCA	All	IV	+1.395	<.001	8	view →
THCA	Male	All	−0.696	<.001	8	view →
READ	All	All	−0.544	.001	7	view →
KIRP	Male	III,IV	−0.502	<.001	6	view →
HNSC	All	II,III,IV	−0.154	<.001	6	view →
COAD	Male	All	−0.208	.001	5	view →
CHOL	All	All	+0.847	<.001	3	view →
LUAD	All	All	+0.154	.006	2	view →
STAD	Female	III,IV	−0.255	.009	1	view →
LIHC	Male	III,IV	−0.042	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IGSF5–KIRC

Open the KIRC breakdown →