IGSF5

Across TCGA pan-cancer cohorts, IGSF5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGSF5 data layer compared with 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGSF5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGSF5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and UCS show a favorable association.

UCEC, ACC, and UCS are the cancer types where IGSF5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.871	0.720	.004	66	view →
ACC	DFS	Median	All	0.391	0.766	<.001	60	view →
UCS	DFS	Median	II,III,IV	0.576	0.147	.001	42	view →
SKCM	OS	Median	All	0.267	0.408	<.001	39	view →
LAML	DFS	Tertile	All	0.161	0.516	<.001	36	view →
LUSC	DFS	Quartile	III,IV	0.358	0.761	.002	32	view →
KIRP	OS	Tertile	All	0.813	0.571	.013	23	view →
ESCA	OS	Median	III,IV	0.725	0.420	.001	22	view →
LUAD	OS	Tertile	II,III,IV	0.459	0.165	.010	16	view →
KICH	OS	Median	II,III,IV	1.000	0.848	.017	15	view →
TGCT	DFS	Median	All	0.940	0.725	.001	14	view →
KIRC	DFS	Quartile	II,III,IV	0.438	0.614	.016	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGSF5–UCEC (DFS)

Open the UCEC breakdown →