IGSF5

Across TCGA cell cohorts, IGSF5 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IGSF5-associated genes across cancer lineages are TNP1, KRT77, and LRRC74A. Each is linked with IGSF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF5-to-partner and partner-to-IGSF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by IGSF5-low versus IGSF5-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF5→partner) and Y-score (partner→IGSF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TNP1 →	+1.110	+4.369	<.001	.008	3	1
SOFT_TISSUE	KRT77 →	+0.005	+4.977	<.001	.002	3	1
SKIN	LRRC74A →	+0.080	+3.345	<.001	.007	3	1
SKIN	OR7A10 →	+0.011	+4.022	<.001	.006	3	1
SKIN	OR10V1 →	+0.013	+4.022	<.001	.006	3	1
SKIN	CYP4F8 →	+0.015	+3.632	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

TNP1 by IGSF5 expression — SOFT_TISSUE

Explore this box plot interactively →